Table 3

Increased risk of cardiovascular events and mortality associated with severe hypoglycemia within the prior 3 months

All participants*Standard treatment group onlyIntensive treatment group only
HR (95% CI)P valueHR (95% CI)HR (95% CI)P value for interaction effect by treatment group
Cardiovascular event1.9 (1.06, 3.52)0.0322.50 (1.0, 6.1)1.7 (0.75, 3.83)>0.2
Cardiovascular mortality3.7 (1.3, 10.4)0.0128.6 (1.9, 37.7)2.1 (0.51, 8.9)0.184
All-cause mortality2.4 (1.1, 5.1)0.0246.7 (2.7, 16.6)0.92 (0.23, 3.8)0.019
  • *Adjusted for treatment group, cardiovascular risk (as estimated by UKPDS score), history of cardiovascular event, insulin at baseline, and eGFR.