Table 1

Age-standardized, diabetes-related lower-extremity amputation rate (per 1,000 adults with diabetes)

Rate (95% CI)APC (95% CI)
20002009/2010*2015First trend APCP valueSecond trend APCP value
All NLEAs
 Total*5.38 (4.93–5.84)3.07 (2.79–3.34)4.62 (4.25–5.00)−5.44 (−6.69 to −4.18)<0.0015.82 (3.46–8.24)<0.001
 Men6.85 (6.08–7.61)4.03 (3.57–4.50)6.97 (6.10–7.84)−5.12 (−6.72 to −3.48)<0.0017.41 (4.32–10.61)<0.001
 Women3.95 (3.55–4.35)2.03 (1.81–2.26)2.62 (2.36–2.89)−6.52 (−7.82 to −5.21)<0.0013.46 (0.90–6.08)0.012
 Age 18–44 years2.86 (2.38–3.34)2.05 (1.71–2.39)4.15 (3.53–4.76)−2.43 (−4.86 to 0.05)0.0549.00 (4.65–13.53)0.001
 Age 45–64 years6.90 (6.17–7.63)3.80 (3.40–4.20)5.43 (4.98–5.88)−5.65 (−7.11 to −4.16)<0.0016.07 (3.57–8.63)<0.001
 Age 65–74 years8.68 (7.64–9.73)4.50 (3.94–5.05)4.53 (4.1–4.96)−7.30 (−7.93 to −6.65)<0.0010.43 (−0.66 to 1.53)0.402
 Age ≥75 years12.64 (10.94–14.34)4.57 (3.99–5.14)4.91 (4.4–5.42)−9.06 (−10.28 to −7.82)<0.001−0.19 (−3.36 to 3.09)0.902
Major NLEAs
 Total*2.28 (2.09–2.47)1.04 (0.94–1.13)1.34 (1.22–1.45)−8.38 (−9.68 to −7.07)<0.0013.18 (0.59–5.84)0.020
 Men2.68 (2.39–2.97)1.29 (1.15–1.43)1.89 (1.66–2.13)−6.92 (−8.31 to −5.50)<0.0016.72 (2.23–11.39)0.007
 Women1.88 (1.69–2.08)0.77 (0.68–0.86)0.85 (0.75–0.95)−9.72 (−11.12 to −8.31)<0.0011.09 (−1.88 to 4.15)0.441
 Age 18–44 years0.84 (0.69–1.00)0.49 (0.4–0.58)1.05 (0.87–1.22)−5.37 (−8.15 to −2.50)0.0029.14 (3.78–14.77)0.003
 Age 45–64 years2.77 (2.47–3.07)1.33 (1.17–1.48)1.59 (1.45–1.74)−7.60 (−9.43 to −5.74)<0.0013.28 (0.09–6.57)0.045
 Age 65–74 years4.33 (3.8–4.85)1.69 (1.47–1.91)1.62 (1.45–1.78)−9.09 (−9.77 to −8.41)<0.001−0.79 (−2.57 to 1.02)0.353
 Age ≥75 years7.57 (6.54–8.61)2.10 (1.81–2.39)1.98 (1.75–2.20)−11.29 (−12.19 to −10.39)<0.001−2.96 (−5.39 to −0.47)0.024
Minor NLEAs
 Total*3.10 (2.81–3.40)2.03 (1.83–2.22)3.29 (3.01–3.57)−3.63 (−4.95 to −2.28)<0.0016.94 (4.53–9.41)<0.001
 Men4.17 (3.65–4.68)2.74 (2.40–3.08)5.08 (4.41–5.75)−3.75 (−5.41 to −2.07)0.0018.59 (5.47–11.80)<0.001
 Women2.07 (1.83–2.30)1.26 (1.11–1.42)1.77 (1.58–1.97)−4.04 (−5.52 to −2.54)<0.0014.57 (1.77–7.44)0.004
 Age 18–44 years2.01 (1.66–2.36)1.56 (1.29–1.82)3.1 (2.63–3.57)−1.32 (−3.78 to 1.20)0.2718.92 (4.59–13.44)0.001
 Age 45–64 years4.12 (3.67–4.58)2.47 (2.21–2.74)3.83 (3.51–4.16)−4.50 (−5.81 to −3.17)<0.0017.38 (5.16–9.65)<0.001
 Age 65–74 years4.35 (3.79–4.92)2.60 (2.27–2.93)2.91 (2.63–3.2)−5.35 (−6.13 to −4.56)<0.0011.96 (0.66–3.27)0.007
 Age ≥75 years5.07 (4.33–5.80)2.47 (2.15–2.78)2.93 (2.61–3.25)−6.38 (−7.93 to −4.80)<0.0011.86 (−2.03 to 5.91)0.320
  • * For 5-point estimates (total NLEAs for men, major NLEAs for men ages 65–74 and ≥75 years, and minor NLEAs for ages ≥75 years), the change point was noted at year 2010 rather than at year 2009.