Table 4

Association of severe hypoglycemia with cardiovascular events and cardiovascular mortality by baseline cardiovascular risk

For cardiovascular risk
Hypoglycemic episodeTen-year cardiovascular risk score, %HR (95% CI)*Absolute risk increase over a 3-month period (per 10 severe hypoglycemic episodes) (95% CI)
Cardiovascular risk
 Any severe hypoglycemic episode in past 3 months7.51.24 (0.49, 3.14)0.023 (0.009, 0.059)
151.56 (0.71, 3.42)0.059 (0.027, 0.128)
252.12 (1.11, 4.04)0.133 (0.069, 0.253)
352.88 (1.57, 5.29)0.252 (0.137, 0.463)
 P value for interaction0.012
CV mortality
 Any severe hypoglycemic episode in past 3 months7.53.05 (0.56, 16.74)0.019 (0.004, 0.107)
153.48 (0.83, 14.69)0.025 (0.006, 0.106)
254.15 (1.30, 13.30)0.062 (0.020, 0.200)
354.95 (1.76, 13.96)0.105 (0.037, 0.295)
 P value for interaction0.2
All-cause mortality
 Any severe hypoglycemic episode in past 3 months7.53.90 (1.41, 10.81)0.077 (0.028, 0.212)
153.41 (1.49, 7.84)0.080 (0.035, 0.183)
252.86 (1.33, 6.16)0.101 (0.047, 0.217)
352.39 (0.93, 6.19)0.137 (0.053, 0.356)
 P value for interaction0.2
  • *A statistically significant increase in the relative association (HR) of severe hypoglycemia with CVD risk (as measured by the UKPDS risk engine) was found for major CVD events.

  • †The absolute risk of adverse events increased greatly with higher CVD risk for all three outcomes. Models include treatment group, severe hypoglycemia in prior 3 months, UKPDS risk, and the UKPDS × severe hypoglycemia interaction. Estimated using UKPDS risk engine.