Table 4

Effect estimates (95% CI) for incident DSPN for 5-unit increase in anthropometric measure and estimated percent mediated by inflammatory biomarker*

Direct effectIndirect effectTotal effectPercent mediated
BMI (kg/m2)
 TNF-α0.013 (0.005; 0.021)0.000 (0.000; 0.002)0.014 (0.005; 0.021)1.6 (−2.0; 9.7)
 IL-60.014 (0.005; 0.024)0.000 (−0.004; 0.003)0.014 (0.005; 0.022)1.3 (−18.6; 20.3)
 CCL70.013 (0.005; 0.020)0.001 (0.000; 0.004)0.014 (0.005; 0.022)6.8 (0.0; 22.2)
 CXCL90.014 (0.005; 0.023)0.000 (−0.003; 0.002)0.014 (0.006; 0.021)7.0 (−16.4; 14.2)
 CXCL100.012 (0.005; 0.019)0.002 (0.000; 0.006)0.014 (0.005; 0.021)10.5 (1.3; 32.8)
 DNER0.015 (0.006; 0.026)−0.001 (−0.005; 0.000)0.014 (0.005; 0.021)−7.5 (−0.4; −25.6)
 CD400.014 (0.005; 0.022)0.000 (−0.002; 0.002)0.014 (0.005; 0.021)1.4 (−9.6; 11.3)
 TNFRSF90.012 (0.005; 0.020)0.001 (0.000; 0.004)0.014 (0.006; 0.021)7.8 (−1.7; 21.6)
Waist circumference (cm)
 TNF-α0.002 (0.000; 0.005)0.000 (0.000; 0.000)0.002 (0.000; 0.005)1.9 (−1.1; 8.8)
 IL-60.002 (0.000; 0.006)0.000 (−0.001; 0.000)0.002 (0.000; 0.005)9.0 (−1.7; 15.2)
 CCL70.002 (0.000; 0.004)0.000 (0.000; 0.001)0.002 (0.000; 0.005)6.9 (0.7; 21.3)
 CXCL90.002 (0.000; 0.005)0.000 (0.000; 0.001)0.002 (0.000; 0.005)2.8 (−10.5; 15.6)
 CXCL100.002 (0.000; 0.004)0.000 (0.000; 0.001)0.002 (0.000; 0.005)11.2 (2.8; 30.2)
 DNER0.002 (0.000; 0.007)0.000 (−0.001; 0.000)0.002 (0.000; 0.005)−9.2 (−1.3; −32.4)
 CD400.002 (0.000; 0.005)0.000 (0.000; 0.000)0.002 (0.000; 0.005)1.5 (−9.7; 13.0)
 TNFRSF90.002 (0.000; 0.005)0.000 (0.000; 0.001)0.002 (0.000; 0.005)5.4 (−5.4; 18.3)
  • Data are β (95% CI) unless otherwise indicated.

  • *Models adjusted for age, sex, socioeconomic status, smoking status, alcohol intake, physical activity, and height (not in models for BMI).

  • †Boldface type indicates statistically significant findings. The mediation effect was interpreted as statistically significant if the 95% CI of the percent mediated effect did not include the null value.