Table 1

Prevalence and autoantibody outcomes at screening by sibling status (N = 48,026)

IT (%)NT (%)FS (%)IT vs. NT OR (95% CI)P value (IT vs. NT)NT vs. FS OR (95% CI)P value (NT vs. FS)
GADA20.25.64.74.31 (2.76–6.73)<0.00010.84 (0.59–1.18)0.302
IA-2A9.43.32.23.01 (1.67–5.42)0.00011.52 (0.98–2.36)0.06
IAA11.94.62.52.78 (1.66–4.67)<0.00011.92 (1.32–2.81)0.0005
≥1 positive Ab23.38.36.23.39 (2.28–5.02)<0.00011.36 (1.02–1.80)0.0365
≥2 positive Ab12.94.02.43.58 (2.11–6.08)<0.00011.72 (1.15–2.58)0.0079
Both IA-2A and IAA positive5.92.10.92.99 (1.43–6.24)0.00232.23 (1.28–3.89)0.0038
  • Ab, islet autoantibody; FS, full siblings; IT, identical twins; NT, nonidentical twins.