Table 1

Baseline characteristics of patients by quartiles of SD of fasting plasma glucose

TotalQ1 (0–5.5 mg/dL)Q2 (5.5–10.5 mg/dL)Q3 (10.5–26.4 mg/dL)Q4 (26.4–240.2 mg/dL)P
n4,9821,2171,2761,2441,245
Age, years65 (60–70)66 (61–71)66 (61–71)65 (60–71)64 (60, 69)<0.0001
Male sex2,840 (57.0)665 (54.6)754 (59.1)748 (60.1)673 (54.1)0.002
Race<0.0001
 White and other3,564 (71.5)926 (76.1)957 (75.0)884 (71.1)797 (64.0)
 Black1,418 (28.5)291 (23.9)319 (25.0)360 (28.9)448 (36.0)
Ethnicity0.511
 Non-Hispanic3,622 (72.7)890 (73.1)946 (74.1)908 (73.0)878 (70.5)
 Hispanic1,035 (20.8)244 (20.1)254 (19.9)254 (20.4)283 (22.7)
 Other325 (6.5)83 (6.8)76 (6.0)82 (6.6)84 (6.8)
Education (number of years)12 (9, 14)12 (9, 14)12 (9, 14)12 (9, 14)12 (9, 13)0.0002
Smoking status<0.0001
 Current1,012 (20.3)243 (20.0)311 (24.4)271 (21.8)187 (15.0)
 Past2,093 (42.0)503 (41.3)535 (41.9)522 (42.0)533 (42.8)
 Never1,877 (37.7)471 (38.7)430 (33.7)451 (36.2)525 (42.2)
Region of residence<0.0001
 East747 (15.0)164 (13.5)192 (15.1)204 (16.4)187 (15.0)
 Midwest1,087 (21.8)316 (26.0)300 (23.5)259 (20.8)212 (17.0)
 South1,464 (29.4)302 (24.8)364 (28.5)373 (30.0)425 (34.1)
 West647 (13.0)178 (14.6)166 (13.0)158 (12.7)145 (11.7)
 Canada127 (2.6)31 (2.6)38 (3.0)32 (2.6)26 (2.1)
 Puerto Rico and Virgin Islands910 (18.3)226 (18.6)216 (16.9)218 (17.5)250 (20.1)
Randomization group0.002
 Chlorthalidone2,363 (47.4)527 (43.3)600 (47.0)599 (48.1)637 (51.2)
 Amlodipine1,377 (27.6)347 (28.5)342 (26.8)358 (28.8)330 (26.5)
 Lisinopril1,242 (24.9)343 (28.2)334 (26.2)287 (23.1)278 (22.3)
Diabetes1,758 (35.3)64 (5.3)156 (12.2)502 (40.4)1,036 (83.2)<0.0001
History of CVD1,276 (25.6)338 (27.8)380 (29.8)318 (25.6)240 (19.3)<0.0001
Use of aspirin1,816 (36.5)472 (38.8)498 (39.0)456 (36.7)390 (31.3)0.0001
Use of hypertension medications4,535 (91.0)1,099 (90.3)1,159 (90.8)1,132 (91.0)1,145 (92.0)0.534
Baseline FBG, mg/dL99 (89–126)93 (87–99)94 (86–104)104 (90–130)153 (113–205)<0.0001
24-month FBG, mg/dL103 (91–134)93 (88–100)96 (89–107)113 (96–136)162 (122–205)<0.0001
48-month FBG, mg/dL105 (93–134)94 (89–101)100 (91–108)117 (102–139)158 (120–205)<0.0001
Cholesterol, mg/dL205.1 (34.3)205.3 (32.2)205.3 (32.6)203.7 (34.6)206.2 (37.5)0.298
Baseline BMI, kg/m229.6 (5.6)28.7 (5.4)28.8 (5.3)30.1 (5.7)30.9 (5.5)<0.0001
Baseline eGFR, mL/min/1.73 m279.4 (18.5)77.0 (16.5)76.6 (16.8)79.1 (18.4)85.0 (20.6)<0.0001
SBP, mmHg136.9 (9.8)136.0 (10.0)136.4 (9.7)137.3 (9.6)137.7 (9.7)<0.0001
  • Data are mean (SD) or median (quartile 1–quartile 3) for continuous variables and n (%) for categorical variables. Q, quartile.