Table 3

VVV in FBG as a categorical variable and incident mortality

Measures of variabilityEstimate of association, HR (95% CI)
Model 1Model 2Model 3Model 4
Quartiles of SD
 Q1 (0–5.5)ReferenceReferenceReferenceReference
 Q2 (5.5–10.5)1.16 (0.70–1.93)1.13 (0.68–1.88)1.13 (0.68–1.88)1.13 (0.68–1.88)
 Q3 (10.5–26.4)1.81 (1.12–2.91)1.83 (1.13–2.95)1.83 (1.13–2.95)1.82 (1.11–2.98)
 Q4 (26.4–240.2)2.03 (1.26–3.28)2.23 (1.36–3.63)2.23 (1.36–3.63)2.22 (1.22–4.04)
Quartiles of ASV
 Q1 (0–6.0)ReferenceReferenceReferenceReference
 Q2 (6.5–12.5)1.10 (0.66–1.84)1.10 (0.66–1.86)1.11 (0.66–1.86)1.10 (0.65–1.84)
 Q3 (13.0–31.5)2.01 (1.26–3.20)2.00 (1.25–3.20)2.00 (1.25–3.20)1.94 (1.20–3.13)
 Q4 (32.0–405.0)1.82 (1.12–2.97)2.00 (1.21–3.29)2.00 (1.21–3.29)1.79 (0.98–3.28)
Quartiles of CV
 Q1 (0–5.6)ReferenceReferenceReferenceReference
 Q2 (5.6–9.9)0.94 (0.56–1.60)0.93 (0.55–1.58)0.93 (0.55–1.58)0.93 (0.55–1.57)
 Q3 (9.9–19.7)1.82 (1.15–2.89)1.83 (1.15–2.92)1.83 (1.15–2.91)1.80 (1.12–2.88)
 Q4 (19.7–94.6)1.97 (1.24–3.14)2.12 (1.32–3.41)2.12 (1.32–3.40)2.00 (1.18–3.41)
Quartiles of VIM
 Q1 (0–7.4)ReferenceReferenceReferenceReference
 Q2 (7.4–12.2)0.96 (0.58–1.58)0.98 (0.60–1.62)0.98 (0.60–1.62)NA
 Q3 (12.2–19.3)1.05 (0.65–1.69)1.03 (0.64–1.67)1.03 (0.64–1.66)NA
 Q4 (19.3–258.7)1.87 (1.21–2.91)1.89 (1.22–2.94)1.89 (1.22–2.93)NA
  • Unit of each quartile of the measure of variability is mg/dL. Model 1: includes adjustment for age, race/ethnicity, sex, region of residence, and antihypertensive medication randomization assignment. Model 2: additional adjustment for education, smoking status, BMI, use of aspirin, average cholesterol, eGFR, history of CVD, and use of antihypertensive medications. Model 3: additional adjustment for average SBP. Model 4: additional adjustment for average FBG. NA, not applicable; Q, quartile.