Table 3

Daytime and nighttime glucose control and insulin delivery during closed-loop with diluted insulin (U20) and closed-loop with standard strength insulin (U100)

Daytime: 6:00 a.m. to 9:59 p.m.Nighttime: 10:00 p.m. to 5:59 a.m.
DilutedStandard strengthDilutedStandard strength
(n = 23)(n = 24)(n = 23)(n = 24)P*
Percent of time with sensor glucose level in range
 3.9–10.0 mmol/L68 ± 1067 ± 880 ± 1077 ± 90.41
 <3.5 mmol/L2.9 ± 1.73.0 ± 1.31.3 ± 1.21.7 ± 1.10.66
Glucose (mmol/L)8.2 ± 0.98.3 ± 0.87.6 ± 0.87.9 ± 0.60.09
Glucose SD (mmol/L)3.3 ± 0.53.4 ± 0.52.6 ± 0.62.8 ± 0.50.17
Total insulin (units/day)14.8 ± 4.916.2 ± 5.72.3 ± 0.92.4 ± 1.10.06
  • Data are mean ± SD.

  • *P value for treatment–by–time of day interaction.