Proportions (95% CI) of those who failed to control* individual risk factors and who failed to control two risk factors simultaneously at 6, 12, and 24 months after second-line ADD initiation
| 6 months | 12 months | 24 months | |
|---|---|---|---|
| Individual failure | |||
| HbA1c | 37 (36–37) | 39 (39–39) | 42 (41–42) |
| LDL | 43 (43–43) | 43 (43–43) | 42 (41–42) |
| Triglycerides | 46 (45–46) | 46 (45–46) | 45 (44–45) |
| SBP | 31 (30–31) | 31 (30–31) | 30 (30–30) |
| Simultaneous failure | |||
| HbA1c + LDL | 61 (60–61) | 62 (62–62) | 63 (62–63) |
| HbA1c + SBP | 53 (53–54) | 55 (55–55) | 57 (57–57) |
| LDL + SBP | 57 (56–57) | 56 (56–57) | 55 (55–56) |
| HbA1c + triglycerides | 61 (61–61) | 62 (62–62) | 63 (62–63) |
↵*Control: HbA1c <7.5% (58 mmol/mol); triglycerides <150 mg/dL; and SBP <130/140 mmHg and LDL <70/100 mg/dL for those with/without history of CVD at the time of second-line ADD initiation. LDL, triglycerides, and SBP proportions are calculated among users of lipid-modifying and antihypertensive drugs.