Table 4

Adjusted HRs (95% CI) for the association between HbA1c and ICH among patients with diabetes

Adjusted for age and sexAdjusted for clinically relevant risk factorsAdjusted for DRS§
HbA1c continuous variable*1.17 (1.13–1.20)1.15 (1.12–1.19)1.14 (1.10–1.17)
HbA1c deciles (D)
 D1: ≤6.0% (≤42 mmol/mol)1.41 (1.13–1.76)1.31 (1.05–1.64)1.27 (1.01–1.59)
 D2: 6.0–6.3% (42–45 mmol/mol)1.19 (0.94–1.50)1.17 (0.93–1.49)1.17 (0.92–1.48)
 D3: 6.3–6.5% (45–48 mmol/mol)1.07 (0.74–1.37)1.09 (0.85–1.39)1.10 (0.86–1.40)
D4: 6.5–6.7% (48–50 mmol/mol)1.0 (reference)1.0 (reference)1.0 (reference)
 D5: 6.7–6.9% (50–52 mmol/mol)1.25 (0.98–1.60)1.27 (1.0–1.63)1.27 (0.99–1.62)
 D6: 6.9–7.2% (52–55 mmol/mol)1.21 (0.95–1.54)1.20 (0.94–1.52)1.18 (0.93–1.51)
 D7: 7.2–7.6% (55–60 mmol/mol)1.35 (1.06–1.71)1.33 (1.05–1.69)1.30 (1.02–1.64)
 D8: 7.6–8.1% (60–65 mmol/mol)1.71 (1.35–2.17)1.66 (1.31–2.12)1.60 (1.26–2.03)
 D9: 8.1–9.3% (65–78 mmol/mol)1.86 (1.48–2.33)1.73 (1.38–2.17)1.63 (1.30–2.03)
 D10: >9.3% (>78 mmol/mol)2.59 (2.07–3.23)2.38 (1.90–2.99)2.19 (1.75–2.73)
  • The reference categories appear in boldface type.

  • †Adjusted for age, sex, ethnicity, SES, alcohol consumption, smoking, obesity, previous ICH, previous stroke/TIA, atrial fibrillation, congestive heart failure, vascular disease, hypertension, chronic kidney disease, chronic liver disease, LDL cholesterol, HDL cholesterol, and use of antiaggregants, anticoagulants, and statins.

  • §DRS, a summary measure of ICH probability, was calculated using a Cox proportional hazards regression model that included all variables in Table 1.

  • *HR for each 1% increase in HbA1c.