Table 1

Characteristics of the study participants at screening

OverallDiluted firstStandard strength first
n241212
Age (years)
 Median (IQR)5 (3–6)5 (3–6)5 (3–6)
 Range1–71–72–7
Male sex, n (%)15 (63)6 (50)9 (75)
Race/ethnicity, n (%)
 White21 (88)11 (92)10 (83)
 Asian1 (4)1 (8)0 (0)
 Mixed2 (8)0 (0)2 (17)
Diabetes duration (years)
 Mean ± SD3.1 ± 1.73.0 ± 1.63.3 ± 1.9
 Range0.5–6.40.5–5.50.5–6.4
Total daily insulin, mean ± SD
 Units/day13.2 ± 4.813.2 ± 4.613.2 ± 5.2
 Units/kg/day0.65 ± 0.140.67 ± 0.150.62 ± 0.14
Total basal insulin, mean ± SD
 Units/day4.9 ± 2.34.7 ± 2.25.1 ± 2.5
 Units/kg/day0.24 ± 0.080.24 ± 0.070.25 ± 0.09
Total bolus insulin, mean ± SD
 Units/day8.2 ± 3.48.4 ± 3.48.1 ± 3.5
 Units/kg/day0.41 ± 0.130.43 ± 0.150.38 ± 0.11
Basal-to-bolus ratio, mean ± SD0.66 ± 0.280.62 ± 0.240.70 ± 0.32
BMI* percentile, median (IQR)73 (4–91)61 (49–75)83 (31–91)
HbA1c, mean ± SD
 %7.4 ± 0.77.7 ± 0.77.1 ± 0.6
 Millimoles per mole of nonglycated hemoglobin57 ± 861 ± 854 ± 6
  • *BMI calculated as the weight in kilograms divided by the square of height in meters.

  • †BMI z score adjusted for age and sex based on 2000 Centers for Disease Control and Prevention growth charts; excludes one subject <2 years of age who received diluted insulin first. For this subject, BMI percentile could not be calculated.