Table 2

Evolution of the main pulmonary function parameters according the response to the intensification of the antidiabetic treatment

Baseline3 monthsMean difference (95% CI)P
Entire population(n = 60)(n = 60)
 FVC (% predicted)77.8 ± 11.380.8 ± 13.03.0 (0.3–5.6)0.025
 FEV1 (% predicted)76.5 ± 13.879.5 ± 13.43.0 (0.5–5.5)0.017
 PEF (% predicted)80.1 ± 21.986.4 ± 19.36.0 (1.8–10.2)0.006
 FEF25–75 (% predicted)65.8 ± 25.266.5 ± 21.8−0.7 (−4.3 to 5.7)0.779
 FEV1/FVC (% predicted)85.3 ± 14.085.8 ± 12.40.5 (−2.5 to 3.6)0.728
 Nonobstructive defect34 (56.6)24 (40.0)0.007
 Abnormal FEV131 (51.6)27 (40.0)<0.001
 Obstructive defect4 (6.6)4 (6.6)1.000
 HbA1c (%)8.8 ± 1.27.7 ± 1.2−1.1 (−1.4 to −0.7)<0.001
 HbA1c (mmol/mol)67.9 ± 13.755.9 ± 15.4−12.0 (−16.4 to −7.6)<0.001
 BMI (kg/m2)32.4 ± 6.132.2 ± 6.1−0.1 (−0.4 to 0.1)0.249
 Waist circumference (cm)112.0 ± 14.2112.1 ± 14.10.1 (−1.0 to 1.1)0.880
 Bonora equation (cm2)253.2 ± 85.8252.6 ± 85.4−0.5 (−1.6 to 1.0)0.273
 CUN-BAE (%)36.3 ± 9.036.4 ± 9.0−0.2 (−0.5 to 0.1)0.275
Good responders(n = 35)(n = 35)
 FVC (% predicted)78.5 ± 12.683.3 ± 14.74.7 (0.5–8.9)0.029
 FEV1 (% predicted)75.6 ± 15.380.9 ± 15.45.2 (1.3–9.1)0.010
 PEF (% predicted)80.4 ± 21.689.2 ± 21.08.8 (2.6–15.0)0.007
 FEF25–75 (% predicted)62.0 ± 27.263.6 ± 23.31.6 (−6.2 to 9.5)0.676
 FEV1/FVC (% predicted)88.3 ± 16.689.4 ± 14.41.1 (−4.1 to 6.3)0.668
 Nonobstructive defect20 (57.1)10 (28.5)0.022
 Abnormal FEV118 (51.4)14 (40.0)<0.001
 Obstructive defect2 (5.7)3 (8.5)0.166
 HbA1c (%)9.1 ± 1.27.1 ± 0.7−2.0 (−2.4 to −1.6)<0.001
 HbA1c (mmol/mol)71.1 ± 14.048.3 ± 8.0−22.7 (−26.9 to −18.5)<0.001
 BMI (kg/m2)32.3 ± 6.431.9 ± 6.3−0.4 (−0.8 to 0.0)0.103
 Waist circumference (cm)112.1 ± 14.6112.0 ± 14.5−0.1 (−1.6 to 1.5)0.941
 Bonora equation (cm2)254.3 ± 89.0253.8 ± 88.5−0.5 (−2.0 to 1.0)0.502
 CUN-BAE (%)36.2 ± 9.635.8 ± 9.5−0.4 (−0.9 to 0.1)0.126
Nonresponders(n = 25)(n = 25)
 FVC (% predicted)76.9 ± 9.377.4 ± 9.30.5 (−1.5 to 2.6)0.586
 FEV1 (% predicted)77.6 ± 11.677.6 ± 9.80.0 (−2.2 to 2.1)0.978
 PEF (% predicted)80.5 ± 22.582.5 ± 16.42.0 (−3.0 to 7.1)0.413
 FEF25–75 (% predicted)71.3 ± 21.370.7 ± 19.3−0.6 (−5.9 to 4.6)0.800
 FEV1/FVC (% predicted)81.2 ± 8.080.9 ± 6.5−0.2 (−2.4 to 1.9)0.818
 Nonobstructive defect14 (56.0)14 (56.0)1.000
 Abnormal FEV113 (52.0)13 (52.0)1.000
 Obstructive defect2 (8.0)1 (4.0)0.763
 HbA1c (%)8.4 ± 1.18.6 ± 1.50.2 (−0.1 to 0.3)0.159
 HbA1c (mmol/mol)63.4 ± 12.466.5 ± 17.03.0 (−0.9 to 7.0)0.159
 BMI (kg/m2)32.5 ± 5.832.6 ± 5.90.1 (−0.1 to 0.4)0.398
 Waist circumference (cm)111.9 ± 13.9112.2 ± 13.80.2 (−1.3 to 1.8)0.718
 Bonora equation (cm2)251.6 ± 82.9250.9 ± 82.7−0.6 (−1.9 to 0.6)0.327
 CUN-BAE (%)37.2 ± 8.337.3 ± 8.20.1 (−0.18 to 0.4)0.412
  • Data are mean ± SD or n (%) unless otherwise indicated.