Table 2

Placental 11β-HSD2 and maternal and fetal/cord plasma cortisol concentrations by mode of delivery, GDM, SGA, or preterm status

Maternal plasma cortisol, nmol/L, 32–35 weeksCord plasma cortisol, nmol/LPlacenta 11β-HSD2, 11β-HSD2/β-actin ratio
nMedian Mean ± SEnMedian Mean ± SEnMedian Mean ± SE
All245562573 ± 11226271318 ± 132460.830.88 ± 0.026
Mode of delivery
 Cesarean72518534 ± 19*64199250 ± 27720.810.90 ± 0.049
 Vaginal173577588 ± 13162306345 ± 141740.840.88 ± 0.030
GDM
 Yes26525518 ± 4226198273 ± 57260.790.95 ± 0.11
 No219567579 ± 10200285324 ± 132200.830.88 ± 0.025
SGA
 Yes16569593 ± 3714313317 ± 28160.750.78 ± 0.087
 No229562571 ± 11212271318 ± 142300.830.89 ± 0.027
Preterm
 Yes13416453 ± 58*10113276 ± 14131.101.10 ± 0.10
 No232568579 ± 11216279320 ± 122330.820.87 ± 0.026
  • Data values in boldface type indicate P < 0.05 compared with the reference group.

  • *P < 0.05; †P < 0.01; ‡P < 0.001 in t tests for differences in log-transformed biomarker data comparing gestational cesarean vs. vaginal, GDM vs. nondiabetic, SGA vs. non-SGA, or preterm vs. term births.