Table 2

HR of suPAR to base-adjusted model, which included sex, age, diabetes duration, LDL, HbA1c, systolic blood pressure, BMI, smoking, UAER, and prescribed RAASi

ModelCardiovascular eventsPProgression in albuminuriaPDecline in eGFR ≥30%PESRDPTotal mortalityP
n (%)94 (14.2)36 (5.5)93 (14.0)23 (3.5)58 (8.7)
Unadjusted3.43 (2.52–4.66)<0.0012.16 (1.28–3.65)0.0044.29 (3.14–5.84)<0.00115.5 (7.93–30.4)<0.0014.37 (2.95–6.46)<0.001
Adjusted3.15 (2.05–4.85)<0.0011.20 (0.55–2.61)0.653.75 (2.46–5.73)<0.00124.4 (8.31–71.8)<0.0013.57 (1.99–6.41)<0.001
Adjusted + eGFR3.03 (1.79–5.12)<0.0011.28 (0.51–3.23)0.612.80 (1.61–4.89)<0.0012.92 (0.77–11.0)0.093.89 (1.87–8.09)<0.001
Adjusted + eGFR + CRP3.13 (1.96–5.45)<0.0011.27 (0.51–3.19)0.612.93 (1.68–5.11)<0.0012.82 (0.73–11.9)0.134.13 (1.96–8.69)<0.001
rIDI (%)22.6<0.0010.680.7514.4<0.0015.70.2723.9<0.001
  • Further stepwise adjustment added eGFR and CRP respectively. HRs were calculated per doubling of suPAR and are presented with 95% CI. rIDI analysis of suPAR, in addition to a base model including sex, age, diabetes duration, LDL, HbA1c, systolic blood pressure, BMI, smoking, UAER, prescribed RAASi, eGFR, and CRP.