Table 2

HRs and 95% lower and upper confidence limits for the effect of the mean HbA1c on the risk of any-CVD and MACE in multivariable models

ModelAny-CVDMACE
HRPC (%)LLULPHRPC (%)LLULP
1: Mean HbA1c and age1.495NA1.3271.685<0.00011.677NA1.4191.982<0.0001
2: model 1 plus family history of MI, mean SBP, (log) Trig, mean LDL, any use of ACE inhibitors, and duration of T1D1.385−22.321.2181.573<0.00011.568−16.151.3111.874<0.0001
3: model 2 plus hypertension, sex, lipid-lowering medication, (log) AER, eGFR, and mean LDLc1.325−34.291.1521.5240.00011.516−23.791.2431.848<0.0001
4: model 3 plus mean pulse1.275−44.331.1051.4720.00091.413−38.921.1541.7310.0008
5: model 4 minus hypertension1.291−41.241.0871.5330.00351.458−32.391.1411.8620.0025
6: mean HbA1c, age, mean pulse, (log) AER, and mean total cholesterol1.229−53.721.0721.4090.00311.334−50.661.1021.6150.0031
  • PC data show % mediation of the HbA1c effect relative to model 1. A “mean” covariate refers to a time-dependent covariate with value equal to the updated weighted mean of the covariate preceding the time of a CVD or MACE event. Other values are the current or most recent value for the covariate preceding the time of an event. LDLc, LDL cholesterol; LL, 95% lower limit; PC, percent change in the risk associated with 1% higher mean HbA1c in each model relative to model 1; Trig, triglycerides; UL, 95% upper limit.