GOP leads to significantly more weight loss than Saline
| Primary comparison (GOP vs. Saline) | Secondary comparisons (GOP vs. RYGB, GOP vs. VLCD) | |||
|---|---|---|---|---|
| GOP | Saline | RYGB | VLCD | |
| Weight (kg) | ||||
| Baseline | 112.6 | 119.3 | 117.8 | 109.0 |
| Week 4 | 108.2 | 116.8 | 107.6 | 100.8 |
| ∆Week 4 | −4.4 (−5.4, −3.5) | −2.5 (−4.1, −0.9) | −10.3 (−11.8, −8.8) | −8.3 (−9.5, −7.1) |
| ∆Week 4 vs. GOP | 1.9 (0.3, 3.5)* | −5.9 (−7.5, −4.2) | −3.9 (−5.3, −2.4) | |
| Weight change (%) | ||||
| ∆Week 4 | −4.0 (−4.8, −3.3) | −2.0 (−3.3, −0.8) | −8.8 (−10.0, −7.7) | −7.6 (−8.3, −6.8) |
| ∆Week 4 vs. GOP | 2.0 (0.7, 3.3)** | −4.8 (−6.2, −3.5) | −3.6 (−4.6, −2.5) | |
| Fat mass (kg) | ||||
| Baseline | 43.4 | 48.3 | 55.5 | 44.4 |
| Week 4 | 40.9 | 47.0 | 49.4 | 39.3 |
| ∆Week 4 | −2.4 (−3.2, −1.7) | −1.3 (−2.9, 0.3) | −6.1 (−7.1, −5.1) | −5.1 (−6.3, −3.9) |
| ∆Week 4 vs. GOP | 1.1 (−0.4, 2.7) | −3.6 (−4.9, −2.3) | −2.7 (−4.2, −1.1) | |
| Muscle mass (kg) | ||||
| Baseline | 63.3 | 67.3 | 59.3 | 60.9 |
| Week 4 | 61.6 | 66.4 | 55.7 | 57.8 |
| ∆Week 4 | −1.7 (−2.8, −0.7) | −0.9 (−1.7, −0.2) | −3.6 ( −5.0, −2.3) | −3.0 (−3.8, −2.3) |
| ∆Week 4 vs. GOP | 0.8 (−0.5, 2.1) | −1.9 (−3.6, −0.3) | −1.3 (−2.5, −0.1) | |
Data are displayed as means (95% CI) for comparisons against baseline and for comparison of treatment effects between groups. ΔWeek 4, treatment effect between baseline and week 4; ΔWeek 4 vs. GOP, difference in treatment effect compared with the GOP arm.
↵*P < 0.05; **P < 0.01 for primary comparison (unpaired t test) of treatment effect between the GOP and Saline arms.