Table 2

GOP leads to significantly more weight loss than Saline

Primary comparison (GOP vs. Saline)Secondary comparisons (GOP vs. RYGB, GOP vs. VLCD)
GOPSalineRYGBVLCD
Weight (kg)
 Baseline112.6119.3117.8109.0
 Week 4108.2116.8107.6100.8
 ∆Week 4−4.4 (−5.4, −3.5)−2.5 (−4.1, −0.9)−10.3 (−11.8, −8.8)−8.3 (−9.5, −7.1)
 ∆Week 4 vs. GOP1.9 (0.3, 3.5)*−5.9 (−7.5, −4.2)−3.9 (−5.3, −2.4)
Weight change (%)
 ∆Week 4−4.0 (−4.8, −3.3)−2.0 (−3.3, −0.8)−8.8 (−10.0, −7.7)−7.6 (−8.3, −6.8)
 ∆Week 4 vs. GOP2.0 (0.7, 3.3)**−4.8 (−6.2, −3.5)−3.6 (−4.6, −2.5)
Fat mass (kg)
 Baseline43.448.355.544.4
 Week 440.947.049.439.3
 ∆Week 4−2.4 (−3.2, −1.7)−1.3 (−2.9, 0.3)−6.1 (−7.1, −5.1)−5.1 (−6.3, −3.9)
 ∆Week 4 vs. GOP1.1 (−0.4, 2.7)−3.6 (−4.9, −2.3)−2.7 (−4.2, −1.1)
Muscle mass (kg)
 Baseline63.367.359.360.9
 Week 461.666.455.757.8
 ∆Week 4−1.7 (−2.8, −0.7)−0.9 (−1.7, −0.2)−3.6 ( −5.0, −2.3)−3.0 (−3.8, −2.3)
 ∆Week 4 vs. GOP0.8 (−0.5, 2.1)−1.9 (−3.6, −0.3)−1.3 (−2.5, −0.1)
  • Data are displayed as means (95% CI) for comparisons against baseline and for comparison of treatment effects between groups. ΔWeek 4, treatment effect between baseline and week 4; ΔWeek 4 vs. GOP, difference in treatment effect compared with the GOP arm.

  • *P < 0.05; **P < 0.01 for primary comparison (unpaired t test) of treatment effect between the GOP and Saline arms.