Table 4

Hospitalization rates for any NLEA in people with ESRD, by diabetes status, and APC, by age, sex, race, and level of amputation

NLEA rate per 100 person-years (95% CI)First trendSecond trend
20002015YearAPC (95% CI)P valueYearAPC (95% CI)P value
Diabetes
 Age-group (years)
  18–445.0 (4.4–5.5)4.2 (3.9–4.5)2000–2015−1.8 (−2.4, −1.3)<0.001NA
  45–647.1 (6.9–7.4)4.7 (4.5–4.8)2000–2012−4.3 (−4.9, −3.7)<0.0012012–20150.9 (−3.8, 5.8)0.68
  65–748.7 (8.4–9.0)4.6 (4.5–4.8)2000–2013−5.3 (−6.0, −4.7)<0.0012013–20152.2 (−9.9, 15.9)0.71
  75+7.8 (7.4–8.2)3.6 (3.4–3.8)2000–2013−6.7 (−7.5, −5.8)<0.0012013–20151.4 (−13.5, 18.8)0.86
 Sex
  Men8.3 (8.0–8.6)5.2 (5.0–5.3)2000–2012−4.3 (−5.0, −3.6)<0.0012012–20150.2 (−5.0, 5.7)0.94
  Women6.7 (6.4–6.9)3.6 (3.4–3.7)2000–2013−5.8 (−6.5, −5.2)<0.0012013–20152.9 (−9.4, 16.7)0.63
  Total7.5 (7.4–7.7)4.4 (4.3–4.5)2000–2013−4.9 (−5.5, −4.3)<0.0012013–20152.7 (−7.5, 14.2)0.58
 Race
  White7.9 (7.7–8.1)4.4 (4.3–4.5)2000–2013−5.2 (−5.8, −4.7)<0.0012013–20154.0 (−6.0, 15.0)0.42
  Black7.3 (7.0–7.6)4.7 (4.6–4.9)2000–2015−3.7 (−4.2, −3.2)<0.001NA
  Other5.4 (5.0–5.9)2.8 (2.6–3.1)2000–2015−5.3 (−5.9, −4.7)<0.001NA
 Level of amputation
  Toe2.0 (1.9–2.1)1.5 (1.4–1.5)2000–2012−2.8 (−3.5, −2.2)<0.0012012–20151.4 (−3.4, 6.4)0.55
  Foot1.0 (0.9–1.1)0.8 (0.8–0.8)2000–2013−2.6 (−3.3, −2.0)<0.0012013–20158.9 (−2.1, 21.1)0.11
  BKA3.4 (3.3–3.5)1.6 (1.6–1.7)2000–2012−6.5 (−7.2, −5.9)<0.0012012–20150.1 (−5.5, 6.1)0.97
  AKA1.9 (1.8–2.0)0.9 (0.9–0.9)2000–20022.9 (−12.9, 21.5)0.7132002–2015−6.7 (−7.5, −5.9)<0.001
No diabetes
 Age-group (years)
  18–440.2 (0.1–0.3)0.4 (0.3–0.4)2000–20153.8 (2.4, 5.1)<0.001NA
  45–641.0 (0.9–1.1)1.2 (1.1–1.2)2000–20150.0 (−0.5, 0.6)0.994NA
  65–742.4 (2.2–2.6)1.8 (1.7–1.9)2000–2015−2.8 (−3.4, −2.1)<0.001NA
  75+2.5 (2.3–2.6)1.5 (1.4–1.5)2000–2013−5.4 (−6.2, −4.6)<0.0012013–20153.4 (−11.4, 20.7)0.64
 Sex
  Men1.6 (1.5–1.7)1.5 (1.4–1.5)2000–2013−2.1 (−2.7, −1.6)<0.0012013–20154.8 (−4.4, 15.0)0.29
  Women1.5 (1.4–1.6)1.0 (0.9–1.0)2000–2015−3.9 (−4.6, −3.2)<0.001NA
  Total1.6 (1.5–1.6)1.3 (1.2–1.3)2000–2013−3.0 (−3.6, −2.3)<0.0012013–20153.9 (−7.0, 16.0)0.47
 Race
  White1.6 (1.5–1.7)1.2 (1.1–1.2)2000–2012−3.9 (−4.7, −3.0)<0.0012012–20152.4 (−4.0, 9.3)0.44
  Black1.6 (1.5–1.7)1.5 (1.4–1.6)2000–20026.3 (−9.6, 25.0)0.4242002–2015−2.1 (−2.7, −1.5)<0.001
  Other0.7 (0.5–0.9)0.6 (0.4–0.7)2000–2015−2.3 (−3.5, −1.1)<0.01NA
 Level of amputation
  Toe0.4 (0.4–0.4)0.4 (0.4–0.4)2000–2015−0.4 (−1.0, 0.1)0.098NA
  Foot0.2 (0.2–0.2)0.2 (0.2–0.2)2000–2013−0.6 (−1.9, 0.6)0.2882013–201510.3 (−7.9, 32.2)0.26
  BKA0.6 (0.5–0.6)0.4 (0.4–0.4)2000–2011−4.0 (−4.9, −3.2)<0.0012011–20151.5 (−2.1, 5.3)0.38
  AKA0.5 (0.5–0.6)0.3 (0.3–0.4)2000–20027.6 (−11.2, 30.5)0.4192002–2015−5.3 (−6.1, −4.4)<0.001
  • All rates are adjusted for age, sex, race, and ethnicity where appropriate. NA, no second trend identified.