Table 2

Dose-gradient associations of time-weighted BP and CAD in individuals with childhood-onset type 1 diabetes

Model 1Model 2
HR (95% CI)P valueHR (95% CI)P value
SBP, mmHg
 <1100.9 (0.6, 1.3)0.5581.1 (0.7, 1.6)0.801
 110 to <120ReferenceReference
 120 to <1301.7 (1.1, 2.5)0.0131.6 (1.1, 2.3)0.027
 130 to <1402.3 (1.4, 3.7)<0.0011.9 (1.2, 3.0)0.011
 ≥1403.3 (2.0, 5.5)<0.0012.6 (1.6, 4.5)<0.001
DBP, mmHg
 <601.1 (0.6, 1.9)0.8130.9 (0.5, 1.7)0.825
 60 to <70ReferenceReference
 70 to <801.9 (1.3, 2.8)<0.0011.8 (1.2, 2.7)0.002
 80 to <905.9 (3.9, 8.9)<0.0014.5 (2.9, 6.9)<0.001
 ≥909.2 (5.2, 16.3)<0.0015.6 (3.0, 10.3)<0.001
MAP, mmHg
 <800.9 (0.6, 1.3)0.5560.9 (0.6, 1.4)0.718
 80 to <90ReferenceReference
 90 to <1002.9 (2.1, 4.2)<0.0012.5 (1.7, 3.5)<0.001
 100 to <1104.1 (2.6, 6.6)<0.0012.9 (1.8, 4.9)<0.001
 ≥11013.9 (7.2, 26.9)<0.0018.5 (4.3, 16.8)<0.001
  • Model 1 was adjusted for age, sex, diabetes duration, and current use of antihypertensive medications. Model 2 was adjusted for the model 1 variables as well as time-weighted HbA1c; ever smoking; updated mean BMI, HDL cholesterol, and non–HDL cholesterol; and raised albuminuria.