Table 3

Risk stratification by time-weighted BP and time-weighted HbA1c for predicting CAD risk in individuals with childhood-onset type 1 diabetes

Model 1Model 2
HR (95% CI)P valueHR (95% CI)P value
SBP/DBP
 BP ≥120/80 vs. <120/80 mmHg2.4 (1.8, 3.3)<0.0011.9 (1.4, 2.6)<0.001
 BP <120/80 mmHg and HbA1c <8%ReferenceReference
 BP ≥120/80 mmHg and HbA1c <8%2.3 (1.3, 4.3)0.0072.0 (1.06, 3.9)0.033
 BP <120/80 mmHg and HbA1c ≥8%2.2 (1.4, 3.6)0.0021.6 (0.97, 2.8)0.071
 BP ≥120/80 mmHg and HbA1c ≥8%5.8 (3.5, 9.7)<0.0013.3 (1.9, 6.0)<0.001
MAP
 MAP ≥90 vs. <90 mmHg3.5 (2.6, 4.7)<0.0012.6 (1.6, 3.5)<0.001
 MAP <90 mmHg and HbA1c <8%ReferenceReference
 MAP ≥90 mmHg and HbA1c <8%4.6 (2.5, 8.4)<0.0013.4 (1.8, 6.5)<0.001
 MAP <90 mmHg and HbA1c ≥8%2.6 (1.6, 4.2)<0.0011.9 (1.1, 3.2)0.016
 MAP ≥90 mmHg and HbA1c ≥8%8.5 (5.1, 14.1)<0.0014.9 (2.7, 8.7)<0.001
  • Model 1 was adjusted for age, sex, diabetes duration, and current use of antihypertensive medications. Model 2 was adjusted for the model 1 variables plus ever smoking; updated mean BMI, HDL cholesterol, and non–HDL cholesterol; and raised albuminuria.