Table 1

Baseline characteristics of the nested case-control subjects selected from the discovery and validation cohorts

DiscoveryValidation
Case subjectsControl subjectsP valueCase subjectsControl subjectsP value
(n = 100)(n = 100)(n = 362)(n = 362)
Age, years59.8 ± 8.058.8 ± 8.40.3857.9 ± 8.957.2 ± 8.90.29
Male sex36 (36.0)36 (36.0)1.00125 (34.5)125 (34.5)1.00
BMI, kg/m225.2 ± 3.325.0 ± 2.90.7024.0 ± 3.723.8 ± 3.40.30
High school or above education28 (28.0)18 (18.0)0.13132 (36.5)124 (34.3)0.38
Current cigarette smoking19 (19.0)20 (20.0)1.0065 (18.0)61 (16.9)0.96
Current alcohol drinking8 (8.0)9 (9.0)0.6039 (10.8)34 (9.4)0.93
Physically active during leisure time11 (11.0)17 (17.0)0.3162 (17.1)54 (14.9)0.73
Family history of diabetes14 (14.0)5 (5.0)0.0550 (13.8)33 (9.1)0.11
SBP, mmHg142.1 ± 18.9139.5 ± 18.90.34129.6 ± 19.4126.2 ± 19.30.02
DBP, mmHg83.9 ± 9.682.7 ± 9.70.3676.8 ± 11.076.3 ± 10.70.53
FPG, mg/dL92.5 ± 8.092.7 ± 6.90.8496.8 ± 7.696.1 ± 7.60.21
2hPG, mg/dL113.1 ± 20.9102.4 ± 20.80.0004114.3 ± 19.1112.2 ± 18.60.13
Fasting HDL cholesterol, mg/dL50.6 ± 12.652.5 ± 12.50.2750.8 ± 17.052.7 ± 15.00.11
Fasting LDL cholesterol, mg/dL129.4 ± 33.2124.0 ± 27.50.21101.7 ± 31.9103.6 ± 30.00.40
Fasting TGs, mg/dL107.1 (83.8–150.4)92.9 (68.0–128.2)0.01100.8 (69.9–145.9)88.7 (64.7–127.1)0.0004
  • Data are mean ± SD or median (interquartile) for the continuous variables, or number (%) for categorical variables. DBP, diastolic blood pressure.