Table 4

Associations of OxGua and 8-isoprostane levels with type 2 diabetes incidence in subgroups defined by sex and age

StratificationEstimateOxGua levelsa8-Isoprostane levelsb
Sex
 MaleHR (95% CI) per 1 SD1.12 (1.02; 1.23)1.03 (0.89; 1.19)
 FemaleHR (95% CI) per 1 SD1.04 (0.99; 1.10)1.05 (1.00; 1.09)
 Interaction term of sex and continuous biomarker variable (per 1 SD)β (SE), P0.077 (0.052), 0.138−0.029 (0.076), 0.699
Age (years)
 <60HR (95% CI) per 1 SD1.01 (0.95; 1.09)1.03 (0.98; 1.10)
 60 to <65HR (95% CI) per 1 SD1.12 (1.01; 1.24)1.09 (0.86; 1.38)
 65 to ≤75HR (95% CI) per 1 SD1.14 (1.05; 1.23)1.22 (1.02; 1.45)
 Interaction term of continuous age (per 1 SD) and biomarker variable (per 1 SD)β (SE), P0.038 (0.025), 0.1230.013 (0.034), 0.702
  • Boldface type indicates statistical significance at P < 0.05.

  • a 1 SD (OxGua levels) = 275 μg/g creatinine. The model for OxGua levels is adjusted for alcohol consumption, triglycerides, and HDL cholesterol.

  • b 1 SD (8-isoprostane levels) = 0.29 nmol/mmol creatinine. The model for 8-isoprostane levels is adjusted for BMI, smoking, alcohol consumption, HbA1c, HDL cholesterol, and eGFR.