Table 2

Mean change in PG concentration and the estimated effect of time difference between meal and prandial bolus

Mean change in interstitial glucose concentration (mg/dL), treatment armEstimate (95% CI) effect of time difference on mean change in interstitial glucose concentration (mg/dL × min)
Faster-CLStandard-CLP valueFaster-CLP valueStandard-CLP value
All meals ΔPG0–1h30.9 (25.8, 38.9)21.7 (7.3, 30.6)0.017−0.57 (−0.99, −0.15)0.011−0.14 (−0.56, 0.28)0.496
All meals ΔPG0–2h258.4 (240.6, 295.1)234.8 (218.6, 296.1)0.280−1.17 (−2.3, 0.01)0.0520.17 (−0.94, 1.29)0.746
Breakfast ΔPG0–1h37.0 (17.4, 46.6)22.7 (18.5, 36.0)0.3030.07 (−0.20, 0.35)0.583−0.01 (−0.42, 0.39)0.944
Breakfast ΔPG0–2h254.2 (222.6, 309.9)237.7 (215.8, 275.0)0.4050.21 (−0.52, 0.95)0.552−0.28 (−1.68, 1.11)0.670
Lunch ΔPG0–1h−3.9 (−12.5, 7.9)6.3 (−4.6, 21.1)0.065−0.16 (−0.51, 0.18)0.325−0.23 (−0.42, −0.04)0.020
Lunch ΔPG0–2h250.9 (194.1, 267.2)264.2 (200.2, 280.3)0.880−0.55 (−1.43, 0.33)0.209−0.97 (−1.36, −0.57)<0.001
Dinner ΔPG0–1h33.1 (25.0, 42.4)31.3 (17.5, 39.0)0.382−0.52 (−0.85, −0.18)0.004−0.15 (−0.58, 0.27)0.445
Dinner ΔPG0–2h250.5 (225.4, 291.9)241.4 (217.1, 271.8)0.603−1.54 (−2.73, −0.36)0.014−0.22 (−1.22, 0.77)0.639
  • The left side of the table shows the influence of treatment arm on a mean change in prandial interstitial glucose concentration. Data are median (IQR). The right side represents the univariate influence of 1 min of the time difference between meals and automated bolus on mean changes in prandial interstitial glucose concentration. Estimates (95% CI) and P values represented were derived from linear regression calculated for each group separately. For example, for the Faster-CL treatment arm in each additional minute between a meal and an automated bolus delivered, ΔPG0–1h calculated for all meals together dropped 0.57 mg/dL.

  • ΔPG, baseline-adjusted interstitial PG increment.