Table 2

The association between T2D and/or prevalent VFs with incident nonvertebral fractures, overall and stratified by BMD category

Outcome: incident nonvertebral fracture, HR (95% CI)
Without T2D or VFs (reference)1.001.001.001.00
With VFs alone1.39 (1.27–1.52)1.61 (1.29–2.00)1.41 (1.26–1.59)1.32 (1.13–1.55)
With T2D alone1.24 (1.09–1.40)1.22 (0.98–1.52)1.28 (1.08–1.52)1.04 (0.71–1.51)
With both T2D and VFs2.42 (1.86–3.15)2.50 (1.44–4.35)2.58 (1.76–3.79)2.06 (1.25–3.38)
With VFs alone (reference)1.001.001.001.00
With both T2D and VFs1.73 (1.32–2.27)1.55 (0.86–2.78)1.82 (1.23–2.70)1.55 (0.93–2.57)
With T2D alone (reference)1.001.001.001.00
With both T2D and VFs1.94 (1.46–2.59)2.04 (1.14–3.65)2.00 (1.33–3.03)1.97 (1.07–3.62)
  • Data are results obrained from Cox regression model adjusted for age (natural splines with 6 df), BMI (natural splines with 5 df), sex, corticosteroid use, antiosteoporotic treatment, and study. The analysis without stratification was additionally adjusted for BMD measured at the femoral neck.