Table 1

Mean postprandial glycemic responses to three types and four amounts of dietary fat in adults with T1D using insulin pump therapy with insulin dosed using individualized ICR as a dual wave

Type of fat (n = 16)Amount of fat (n = 15)
MUFAPUFASFAP value0 g fat20 g fat40 g fat60 g fatP value
Dosing approachICRICRICRICRICRICRICR
Mean insulin dose (units)6.1 ± 0.46.1 ± 0.46.1 ± 0.46.2 ± 0.46.2 ± 0.46.2 ± 0.46.2 ± 0.4
Mean insulin dual-wave split (%/%)50/5050/5050/5050/5050/5050/5050/50
Mean insulin dual-wave duration (min)120120120120120120120
5-h iAUC (mmol/L·min)570 ± 115556 ± 108473 ± 1010.595613 ± 73644 ± 115551 ± 79930 ± 1590.059
0–120-min iAUC (mmol/L·min)252 ± 54278 ± 47243 ± 420.761409 ± 35312 ± 59227 ± 37254 ± 540.004*
120–300-min iAUC (mmol/L·min)435 ± 93399 ± 87340 ± 830.491356 ± 57473 ± 90434 ± 66803 ± 1360.008*
Incremental mean BGL (mmol/L)1.2 ± 0.41.1 ± 0.50.8 ± 0.40.6361.3 ± 0.31.4 ± 0.41.3 ± 0.32.3 ± 0.50.110
Incremental SD (mmol/L)2.2 ± 0.32.3 ± 0.22.1 ± 0.20.7972.8 ± 0.22.4 ± 0.31.9 ± 0.22.2 ± 0.30.014*
Incremental peak BGL (mmol/L)4.6 ± 0.74.9 ± 0.74.2 ± 0.60.6065.9 ± 0.45.3 ± 0.84.5 ± 0.55.6 ± 0.80.239
Time to peak (min)118 ± 1399 ± 7101 ± 50.08683 ± 5104 ± 8130 ± 6152 ± 10<0.001*
Nadir (mmol/L)−1.8 ± 0.4−1.9 ± 0.4−2.3 ± 0.50.482−2.5 ± 0.5−1.9 ± 0.4−1.4 ± 0.5−0.9 ± 0.20.018*
Time to nadir (min)192 ± 37201 ± 34180 ± 370.825242 ± 22200 ± 35165 ± 3578 ± 300.009*
CV (%)25 ± 038 ± 036 ± 0<0.001*40 ± 038 ± 035 ± 038 ± 00.070
J-index5.2 ± 1.45.0 ± 1.24.0 ± 1.30.5306.6 ± 1.65.0 ± 1.24.2 ± 1.09.0 ± 2.50.130
Incremental amplitude (mmol/L)6.5 ± 0.76.8 ± 0.66.5 ± 0.60.8357.2 ± 0.86.8 ± 0.65.9 ± 0.66.5 ± 0.80.010*
Incidence of hypoglycemia [n (%)]5 (29)3 (18)3 (18)0.624⊥7 (47)3 (20)1 (7)0 (0)<0.001*
  • Data are mean ± SE unless otherwise indicated.

  • * Statistically significant, P < 0.05.

  • Tested by χ2.