Table 3

Associations of 8-isoprostane levels with type 2 diabetes incidence

Modeling (nmol/mmol creatinine)ntotalncasesModel 1aModel 2bModel 3c
Per 1 SDd7,8281,3281.04 (1.00; 1.09)1.05 (1.01; 1.10)1.05 (1.00; 1.10)
≤0.151,567232RefRefRef
>0.15 to ≤0.181,5642571.06 (0.89; 1.27)1.06 (0.89; 1.27)1.06 (0.89; 1.27)
>0.18 to ≤0.231,5662851.19 (0.99; 1.42)1.19 (0.99; 1.42)1.19 (0.99; 1.42)
>0.23 to ≤0.291,5662751.14 (0.95; 1.36)1.14 (0.96; 1.36)1.13 (0.95; 1.36)
>0.291,5652791.14 (0.95; 1.36)1.14 (0.96; 1.37)1.13 (0.94; 1.36)
  • Data are HR (95% CI) unless otherwise indicated. Boldface type indicates statistical significance at P < 0.05. Ref, reference.

  • a Model adjusted for BMI, smoking, alcohol consumption, HbA1c, HDL cholesterol, and eGFR.

  • b Model adjusted for BMI, smoking, alcohol consumption, use of antihypertensive medication, systolic blood pressure, HbA1c, triglycerides, HDL cholesterol, eGFR, and family history of diabetes.

  • c Model adjusted for all baseline characteristics shown in Table 1.

  • d 1 SD = 0.29 nmol/mmol creatinine.