Table 1

Baseline demographics and medications

Liraglutide 3.0 mg (n = 198)Placebo (n = 198)
Male sex, n (%)90 (45.5)99 (50.0)
Mean age, years (SD)55.9 (11.3)57.6 (10.4)
Race, n (%)
 White174 (87.9)180 (90.9)
 Black17 (8.6)11 (5.6)
 Asian3 (1.5)5 (2.5)
Ethnicity not Hispanic or Latino, n (%)155 (78.3)169 (85.4)
Mean body weight, kg (SD)*100.6 (20.8)98.9 (19.9)
Mean BMI, kg/m2 (SD)35.9 (6.5)35.3 (5.8)
Mean waist circumference, cm (SD)114.8 (13.7)114.2 (13.2)
Mean HbA1c, % (SD)7.9 (1.1)8 (1.0)
Mean HbA1c, mmol/mol (SD)63.0 (11.5)63.6 (11.3)
Mean FPG, mmol/L (SD)7.8 (2.2)8.1 (2.5)
Mean FPG, mg/dL (SD)141 (40)146 (46)
Mean diabetes duration, years (SD)11.4 (6.8)12.8 (6.9)
Mean heart rate, bpm (SD)74.0 (10.0)75.0 (11.0)
Mean SBP, mmHg (SD)129.0 (14.0)132.0 (16.0)
Mean DBP, mmHg (SD)78.0 (9.0)78.0 (9.0)
Mean total cholesterol, mmol/L (SD)4.5 (1.0)4.4 (0.9)
Mean total cholesterol, mg/dL (SD)172 (39)171 (36)
Mean LDL cholesterol, mmol/L (SD)2.4 (0.9)2.4 (0.8)
Mean LDL cholesterol, mg/dL (SD)94 (33)94 (29)
Mean HDL cholesterol, mmol/L (SD)1.2 (0.3)1.2 (0.3)
Mean HDL cholesterol, mg/dL (SD)45 (12)45 (11)
Mean VLDL cholesterol, mmol/L (SD)0.9 (0.4)0.8 (0.4)
Mean VLDL cholesterol, mg/dL (SD)33 (16)32 (15)
Mean triglycerides, mmol/L (SD)2.0 (1.2)1.9 (1.0)
Mean triglycerides, mg/dL (SD)174 (105)168 (89)
Mean free fatty acids, mmol/L (SD)0.6 (0.2)0.6 (0.3)
Mean free fatty acids, mg/dL (SD)15.9 (6.9)15.5 (7.3)
Antidiabetic medications at screening, n (%)
 Biguanides175 (88.4)176 (88.9)
 SUs68 (34.3)71 (35.9)
 SGLT2i44 (22.2)44 (22.2)
 Thiazolidinediones4 (2.0)6 (3.0)
 Combination BG-lowering drugs (oral)4 (2.0)3 (1.5)
 α-Glucosidase inhibitors2 (1.0)0 (0.0)
 Other BG-lowering drugs, excluding insulins1 (0.5)5 (2.5)
Insulins/analogs (injection), n (%)
 Long-acting180 (90.9)184 (92.9)
 Intermediate-acting18 (9.1)14 (7.1)
  • DBP, diastolic blood pressure; SBP, systolic blood pressure; SGLT2i, sodium–glucose cotransporter 2 inhibitor.

  • * Body weight measurements include both fasting and nonfasting measures.

  • Safety analysis set; liraglutide, n = 195; placebo, n = 197.