Table 3

Number of events, incidence rate per 10,000 person-years by type, and adjusted HR compared with control patients, adjusted for sex, age, and BMI

End pointeGFR (mL/min/1.73 m2)*GBPControlHR (95% CI)P value
Half eGFR (MDRD)≥9032 (33.59)64 (49.63)0.68 (0.44, 1.05)0.0788
90–6011 (19.22)31 (44.71)0.47 (0.23, 0.95)0.0356
60–455 (93.88)6 (70.42)1.42 (0.40, 5.03)0.5835
45–301 (61.87)11 (352.92)0.13 (0.02, 1.03)0.0538
<302 (2.22)8 (22.86)0.10 (0.02, 0.49)0.0046
Half eGFR (CKD-EPI)≥9018 (18.84)36 (27.84)0.69 (0.39, 1.22)0.2039
90–6013 (22.74)41 (59.32)0.41 (0.22, 0.78)0.0063
60–455 (93.88)7 (82.33)1.26 (0.38, 4.21)0.7110
45–301 (61.87)12 (386.52)0.12 (0.02, 0.97)0.0463
<303 (3.33)9 (25.73)0.14 (0.04, 0.52)0.0036
Macroalbuminuria≥90102 (110.48)268 (221.22)0.48 (0.38, 0.61)<0.0001
90–6072 (130.93)157 (244.41)0.50 (0.38, 0.66)<0.0001
60–4529 (661.83)38 (504.37)1.12 (0.68, 1.82)0.6621
45–3014 (1,147.50)32 (1,471.47)0.81 (0.42, 1.56)0.5245
<3088 (101.35)80 (244.03)0.39 (0.29, 0.53)<0.0001
Acute kidney failure≥907 (7.31)25 (19.32)0.36 (0.15, 0.83)0.0168
90–6015 (26.27)30 (43.25)0.61 (0.32, 1.14)0.1226
60–453 (55.00)6 (69.92)0.94 (0.22, 3.98)0.9321
45–301 (60.42)6 (190.21)0.39 (0.04, 3.42)0.3972
<3026 (29.07)7 (19.96)1.24 (0.54, 2.88)0.6143
CKD≥902 (2.09)6 (4.63)0.45 (0.09, 2.34)0.3417
90–6011 (19.18)28 (40.37)0.48 (0.23, 0.97)0.0424
60–456 (110.87)20 (241.33)0.38 (0.15, 0.97)0.0419
45–306 (386.90)28 (1,033.37)0.29 (0.11, 0.71)0.0074
<3027 (30.18)32 (92.89)0.28 (0.16, 0.47)<0.0001
Diabetic nephropathy≥902 (2.09)14 (10.81)0.22 (0.05, 0.99)0.0485
90–6008 (11.51)0.00 (0.00, —)0.9930
60–452 (36.33)9 (106.71)0.30 (0.06, 1.43)0.1313
45–301 (60.97)8 (258.30)0.19 (0.02, 1.61)0.1286
<3012 (13.36)14 (40.13)0.34 (0.15, 0.75)0.0079
Severe renal disease≥9010 (10.45)30 (23.21)0.42 (0.21, 0.88)0.0204
90–6024 (42.15)55 (79.83)0.52 (0.32, 0.86)0.0098
60–4510 (189.88)28 (341.15)0.51 (0.24, 1.07)0.0754
45–307 (453.82)33 (1,281.85)0.30 (0.13, 0.70)0.0055
<3047 (52.96)41 (119.43)0.39 (0.25, 0.60)<0.0001
Severe renal disease or half eGFR value (MDRD)≥9039 (40.99)86 (66.96)0.59 (0.41, 0.87)0.0077
90–6029 (51.04)72 (104.95)0.51 (0.33, 0.79)0.0024
60–4511 (211.45)28 (342.66)0.57 (0.28, 1.15)0.1171
45–308 (532.92)33 (1,289.79)0.37 (0.17, 0.83)0.0153
<3048 (54.09)41 (119.43)0.40 (0.26, 0.61)<0.0001
Severe renal disease or half eGFR value (CKD-EPI)≥9026 (27.25)60 (46.59)0.57 (0.36, 0.90)0.0168
90–6031 (54.62)81 (118.37)0.48 (0.31, 0.73)0.0006
60–4511 (211.45)29 (355.70)0.55 (0.27, 1.12)0.1007
45–308 (532.92)34 (1,335.28)0.36 (0.16, 0.80)0.0120
<3048 (54.12)41 (119.45)0.40 (0.26, 0.61)<0.0001
Hemodialysis or peritoneal dialysis≥9004 (3.08)0.00 (0.00, —)0.9958
90–6003 (4.30)0.00 (0.00, —)0.9957
60–4501 (11.60)0.00 (0.00, —)0.9986
45–301 (60.68)8 (254.26)0.15 (0.02, 1.24)0.0788
<305 (5.55)11 (31.47)0.19 (0.06, 0.56)0.0027
CVD≥9081 (86.44)133 (105.13)0.73 (0.55, 0.96)0.0260
90–6075 (135.04)123 (184.82)0.66 (0.49, 0.89)0.0056
60–4517 (331.56)23 (287.14)1.11 (0.58, 2.12)0.7494
45–304 (259.25)22 (778.56)0.30 (0.10, 0.90)0.0323
<30114 (131.96)45 (131.42)0.89 (0.62, 1.27)0.5087
Congestive heart failure≥9021 (22.02)71 (55.37)0.35 (0.21, 0.57)<0.0001
90–6015 (26.21)83 (122.29)0.22 (0.12, 0.38)<0.0001
60–456 (110.67)29 (360.76)0.33 (0.14, 0.82)0.0165
45–304 (250.82)17 (569.27)0.49 (0.16, 1.51)0.2127
<3040 (44.83)33 (95.41)0.37 (0.23, 0.60)<0.0001
Fatal kidney disease≥901 (1.04)5 (3.85)0.34 (0.04, 3.13)0.3396
90–604 (6.96)8 (11.46)0.76 (0.21, 2.74)0.6777
60–4502 (23.19)0.00 (0.00, —)0.9979
45–301 (60.33)6 (182.06)0.34 (0.04, 2.96)0.3317
<306 (6.65)11 (31.26)0.18 (0.06, 0.50)0.0010
Fatal CVD≥908 (8.35)32 (24.65)0.30 (0.14, 0.66)0.0026
90–6013 (22.62)33 (47.27)0.45 (0.23, 0.86)0.0151
60–45012 (139.15)0.00 (0.00, —)0.9927
45–301 (60.33)4 (121.37)0.48 (0.05, 4.62)0.5287
<309 (9.98)12 (34.10)0.28 (0.11, 0.70)0.0066
All-cause mortality≥9057 (59.41)136 (104.64)0.53 (0.39, 0.72)<0.0001
90–6054 (93.81)108 (154.52)0.65 (0.46, 0.91)0.0115
60–454 (71.93)32 (370.51)0.24 (0.08, 0.68)0.0072
45–304 (240.46)24 (719.62)0.40 (0.13, 1.19)0.0996
<3064 (70.88)51 (144.73)0.35 (0.24, 0.51)<0.0001
  • * Number of patients in the eGFR strata (GBP and control groups, respectively): eGFR ≥90 mL/min/1.73 m2, 2,144 and 2,805; eGFR 90–60 mL/min/1.73 m2, 1,274 and 1,493; eGFR 60–45 mL/min/1.73 m2, 125 and 190; eGFR 45–30 mL/min/1.73 m2, 35 and 79; and eGFR <30 mL/min/1.73 m2, 1,743 and 754.