Table 2

Sensitivity analyses of the primary outcome

Sensitivity analysesNo. of excluded trials (reference nos.)No. of included trials (reference nos.)HR (95% CI)PNo. of included trials (reference nos.)RR (95% CI)P
Overall analysis03 (15,16,29)0.88 (0.78, 0.99)0.048 (15,16,2530)0.89 (0.80, 0.99)0.03
Excluding studies with high risk of bias5 (2528,30)3 (15,16,29)0.88 (0.78, 0.99)0.043 (15,16,29)0.91 (0.81, 1.01)0.08
Excluding small trial (participants <200)5 (2528,30)3 (15,16,29)0.88 (0.78, 0.99)0.043 (15,16,29)0.91 (0.81, 1.01)0.08
Excluding quasi/cluster-randomized trials03 (15,16,29)0.88 (0.78, 0.99)0.048 (15,16,2530)0.89 (0.80, 0.99)0.03
Excluding trials with follow-up <1 year1 (30)3 (15,16,29)0.88 (0.78, 0.99)0.047 (15,16,2529)0.90 (0.81, 1.00)0.04
Using random-effects models03 (15,16,29)0.88 (0.78, 0.99)0.048 (15,16,2530)0.90 (0.81, 1.00)0.04
Excluding trials reported as abstract1 (16)2 (15,29)0.89 (0.77, 1.02)0.097 (15,2530)0.89 (0.80, 1.00)0.04
Excluding the largest trial1 (15)2 (16,29)0.88 (0.74, 1.05)0.177 (16,2530)0.87 (0.73, 1.02)0.09