Table 1

Patients’ characteristics

CONSAIDSIDDSIRDMODMARD
n832542561240254
Genotype frequency (CC/CG/GG), n54/24/5137/105/1212/13/022/33/6136/91/13141/95/18
Female sex, n (%)26 (31)117 (46)5 (20)17 (28)108 (45)71 (28)
Age (years)47 ± 1437 ± 1243 ± 1256 ± 1045 ± 1058 ± 7
BMI (kg/m2)28.2 ± 5.725.0 ± 4.327.1 ± 3.734.5 ± 3.634.9 ± 6.327.4 ± 3.5
WHR0.92 ± 0.090.88 ± 0.090.94 ± 0.061.00 ± 0.070.97 ± 0.080.95 ± 0.07
Fasting blood glucose (mg/dL)91 ± 15136 ± 46187 ± 60117 ± 21130 ± 28123 ± 24
HbA1c (%)5.3 ± 0.3*6.6 ± 1.2*8.8 ± 1.3*6.2 ± 0.76.5 ± 0.96.3 ± 0.7
HOMA-IR (a.u.)1.48 ± 0.71*0.99 ± 0.87*1.97 ± 0.984.48 ± 1.212.77 ± 1.011.94 ± 0.75*
HOMA-B (a.u.)122 ± 3946 ± 31*39 ± 21*170 ± 4698 ± 37*83 ± 30*
hs-CRP (mg/dL)0.1 (0.1; 0.2)0.1 (0.1; 0.2)0.2 (0.1; 0.4)0.4 (0.2; 0.6)0.3 (0.2; 0.7)0.2 (0.1; 0.3)
Total cholesterol (mg/dL)205 ± 35185 ± 38206 ± 29197 ± 42203 ± 44201 ± 42
LDL cholesterol (mg/dL)129 ± 33109 ± 34*131 ± 29123 ± 37130 ± 37129 ± 36
HDL cholesterol (mg/dL)61 ± 18*62 ± 18*51 ± 12*42 ± 945 ± 1251 ± 14*
Triglycerides (mg/dL)93 (62; 148)*73 (53; 106)*149 (79; 205)176 (119; 239)140 (97; 193)*117 (83; 161)*
ALT (units/L)25 ± 1121 ± 826 ± 1629 ± 1325 ± 1124 ± 10
AST (units/L)28 ± 19*23 ± 17*34 ± 1842 ± 1737 ± 22*29 ± 16*
GGT (units/L)26 ± 18*22 ± 23*36 ± 2449 ± 4446 ± 6235 ± 33*
  • Data are shown as absolute numbers, percentages, mean ± SD, or median (interquartile range), as applicable. a.u., arbitrary units; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, γ-glutamyl transferase; HOMA-IR, HOMA of insulin resistance; HOMA-B, HOMA of β-cell function; WHR, waist-to-hip ratio.

  • * P < 0.05 vs. SIRD (Dunnett test).