Table 4

Hazard ratios (95% CIs) for new-onset diabetes in categories stratified by intratrial mean serum 25(OH)D level in D2d study participants assigned to placebo

<50 nmol/L (n = 225)50–74 nmol/L (n = 378)75–99 nmol/L (n = 265)100–124 nmol/L (n = 94)≥125 nmol/L (n = 22)
Median level40.063.885.0108.4134.1
Model 11.20 (0.87–1.66)Reference1.09 (0.82–1.46)0.69 (0.42–1.14)0.64 (0.24–1.75)
Model 21.28 (0.91–1.81)Reference1.05 (0.78–1.41)0.68 (0.41–1.14)0.60 (0.22–1.67)
Model 31.24 (0.89–1.76)Reference1.05 (0.78–1.41)0.69 (0.41–1.16)0.62 (0.22–1.73)
Model 41.23 (0.87–1.75)Reference1.04 (0.77–1.39)0.67 (0.40–1.13)0.48 (0.15–1.56)
Model 51.23 (0.86–1.75)Reference1.03 (0.76–1.38)0.67 (0.40–1.12)0.47 (0.15–1.52)
  • Model 1: no adjustment. Model 2: adjusted for site, BMI (at baseline), race (White, Black, other). Model 3: additionally adjusted for sex and age (at baseline). Model 4: additionally adjusted for physical activity (at baseline). Model 5: additionally adjusted for statin use (at baseline). To convert the values for 25(OH)D to ng/L, divide by 2.496.