Table 1

Baseline demographic and clinical characteristics of patients

CharacteristicStandard of careSitagliptinP value
Age (years)69 ± 1.069 ± 0.90.83
Patients ≥70 years of age, n (%)90 (53)92 (54)0.91
Male sex, n (%)115 (68)123 (73)0.40
Duration of diabetes (years)8.7 ± 1.29.2 ± 0.80.73
Coexisting conditions, n (%)
 Cardiovascular disease53 (38)65 (40)0.63
 Chronic kidney disease34 (28)34 (21)0.26
 Hypertension80 (67)118 (74)0.23
 Cancer17 (14)27 (17)0.62
Glucose-lowering medications, n (%)
 Metformin63 (39)79 (44)0.16
 Insulin48 (30)39 (22)0.15
 Other oral antidiabetic agents50 (31)61 (34)0.25
Antihypertensive drugs, n (%)
 ACE inhibitors29 (50)38 (38)0.13
 β-Blockers34 (56)32 (33)0.007
 Diuretics30 (52)36 (38)0.13
Antiplatelet drugs, n (%)29 (49)39 (40)0.32
Anticoagulant drugs, n (%)52 (77)74 (68)0.17
Respiratory rate (breaths/min)25.8 ± 0.723.7 ± 0.60.04
Clinical score (0–7)4.4 ± 0.14.4 ± 0.080.88
BMI (kg/m2)30 ± 0.629 ± 0.40.18
HbA1c (%)7.5 ± 0.17.5 ± 0.10.66
HbA1c (mmol/mol)58.6 ± 1.258.6 ± 1.30.98
Glycemia (mg/dL)188 ± 6.8180 ± 6.70.38
Serum creatinine (mg/dL)1.4 ± 0.081.2 ± 0.080.10
Lymphocyte count (× 10−9/L)0.9 ± 0.061.1 ± 0.170.13
CRP (mg/L)19 ± 2.314 ± 0.70.01
D-dimer (μg/mL)6,377 ± 1,9285,835 ± 1,3910.82
Interleukin-6 (ng/L)95 ± 9.789 ± 10.70.71
LDH (units/L)423 ± 43387 ± 160.43
Ferritin (μg/mL)601 ± 48688 ± 970.43
AST (units/L)42 ± 3.043 ± 2.60.79
ALT (units/L)38 ± 2.440 ± 2.90.74
Procalcitonin (ng/mL)12.7 ± 4.48.3 ± 3.30.42
Oxygen saturation (%)92 ± 0.792 ± 0.50.31
  • Data are mean ± SEM unless otherwise indicated. Other oral antidiabetic agents are metformin, sulfonylureas, GLP-1-receptor agonists, DPP-4 inhibitors, sodium–glucose cotransporter 1 inhibitors, glinides, and thiazolidinediones.

  • LDH, lactate dehydrogenase.