Table 3

HRs for all-cause mortality according to different levels of TIR among subpopulations

TIRP for trendP for interaction
>85%71–85%51–70%≤50%
Age, years>0.05
 <501.000.75 (0.20–2.85)1.29 (0.38–4.45)4.33 (1.46–12.8)0.005
 ≥501.001.36 (1.08–1.72)1.41 (1.12–1.78)1.97 (1.58–2.46)<0.001
Sex<0.05
 Men1.001.52 (1.13–2.05)1.41 (1.04–1.91)2.34 (1.76–3.12)<0.001
 Women1.000.90 (0.62–1.29)1.17 (0.84–1.64)1.24 (0.89–1.72)0.203
History of CVD or cancer>0.1
 Yes1.001.31 (0.90–1.89)1.29 (0.90–1.84)1.70 (1.20–2.41)<0.001
 No1.001.20 (0.89–1.61)1.32 (0.99–1.77)1.95 (1.48–2.57)<0.001
Use of insulin>0.1
 Yes1.000.96 (0.72–1.29)0.94 (0.71–1.26)1.33 (1.01–1.74)0.001
 No1.001.29 (0.88–1.90)1.52 (1.00–2.31)2.06 (1.29–3.29)0.018
Use of antihypertensive drugs>0.1
 Yes1.001.08 (0.82–1.43)1.06 (0.81–1.39)1.55 (1.20–2.00)<0.001
 No1.001.61 (1.05–2.47)2.12 (1.40–3.20)2.76 (1.84–4.14)<0.001
  • Adjusted for age, sex, smoking, diabetes duration, BMI, systolic blood pressure, triglycerides, HDL cholesterol, LDL cholesterol, history of cancer, history of CVD, and use of antihypertensive drugs, aspirin, and statins, other than the variable for stratification.