Table 2

HRs for all-cause and cardiovascular mortality according to different levels of TIR

TIRP for trendTIR as a continuous variable (each 10% decrease)
>85%71–85%51–70%≤50%
All-cause mortality
 Number of participants1,4461,4801,6371,662
 Number of deaths126185219308
 Person-years10,704.810,708.611,493.011,300.4
Adjusted HRs (95% CIs)
 Model 11.001.26 (1.01–1.59)1.39 (1.12–1.74)1.98 (1.60–2.44)<0.0011.10 (1.07–1.13)
 Model 21.001.23 (0.98–1.55)1.30 (1.04–1.63)1.83 (1.48–2.28)<0.0011.08 (1.05–1.12)
Cardiovascular mortality
 Number of deaths376481105
Adjusted HRs (95% CIs)
 Model 11.001.43 (0.95–2.14)1.66 (1.12–2.45)2.15 (1.47–3.13)<0.0011.08 (1.03–1.13)
 Model 21.001.35 (0.90–2.04)1.47 (0.99–2.19)1.85 (1.25–2.72)0.0151.05 (1.00–1.11)
  • Model 1 adjusted for age and sex; model 2 adjusted for age, sex, smoking, diabetes duration, BMI, systolic blood pressure, triglycerides, HDL cholesterol, LDL cholesterol, history of cancer, history of CVD, and use of antihypertensive drugs, aspirin, and statins.