Randomized controlled prevention studies in T2DM in Asian populations using lifestyle intervention
| Study population characteristics | Mean duration | Participants by treatment group | Cumulative incidence of diabetes | Relative risk reduction | |
|---|---|---|---|---|---|
| Study (year) (Ref) | (years) | (n) | (%) | (%) | |
| Da Qing IGT and Diabetes Study (1997) (102) | Chinese: | Total n = 577 | Control: 67.7 | Diet: 31.0 | |
| BMI: 26.0 | 6 | Control: 133 | Diet: 43.8 | Exercise: 46.0 | |
| Age: 45.0 | Diet: 130 | Exercise: 41.1 | Diet + exercise: 42.0 | ||
| Cluster randomized by clinic | Exercise: 141 | Diet + exercise: 46.0 | |||
| Diet + exercise: 126 | |||||
| Da Qing Diabetes Prevention Study (2008) (103) | Control | Control: 138 | Control: 93.0 | 43.0 | |
| BMI: 24.4 | 20 | Intervention: 439 | Intervention: 80.0 | ||
| Intervention | |||||
| BMI: 24.5 | |||||
| Da Qing Diabetes Prevention Study (2014) (103) | Control | Total n = 568 (by interview from medical records) | Control: 89.9 | 45.0 | |
| BMI: 25.7 | 23 | Control: 138 | Intervention: 72.6 | ||
| Intervention | Intervention: 430 | CVD mortality | 41.0 | ||
| BMI: 26.2 | Control: 19.6 | ||||
| Intervention: 11.9 | |||||
| All-cause mortality | 29.0 | ||||
| Control: 38.4 | |||||
| Intervention: 28.0 | |||||
| IDPP-1 (2006) (104) | BMI: 25.8 | 2.6 (median) | Total n = 531 | Control: 55.0 | LSM: 28.5 |
| Age: 45.9 | Control: 136 | LSM: 39.3 | Metformin: 26.4 | ||
| Persistent IGT, individual randomization | LSM: 133 | Metformin: 40.5 | LSM + metformin: 28.2 | ||
| Metformin: 133 | LSM + metformin: 39.5 | ||||
| LSM + metformin: 129 | |||||
| Indian SMS study (2013) (108) | BMI: 25.8 | 2 | Control: 266 | Control: 27.4 | |
| Age: 45.9 | Intervention: 271 | Intervention: 18.5 | 36.0 | ||
| Persistent IGT, men | |||||
| Japanese prevention study (2005) (105) | Japanese men: | 4 | Control: 102 | Control: 9.3 | 67.4 |
| BMI: 23.5 | Intervention: 356 | Intervention: 3.0 | |||
| Age: 51.5 | |||||
| IGT, individual randomization | |||||
| Zensharen Study for Prevention of Lifestyle Diseases (2011) (106) | Japanese men: | 3 | Control: 330 | Control: 16.6 | 44.0 |
| BMI: 27.0 | Intervention: 311 | Intervention: 12.2 | |||
| Age: 49.0 | |||||
| IGT, individual randomization |
Age given as mean (years) and BMI given as mean (kg/m2). CVD, cardiovascular disease.