Table 4

Randomized controlled prevention studies in T2DM in Asian populations using lifestyle intervention

Study population characteristicsMean durationParticipants by treatment groupCumulative incidence of diabetesRelative risk reduction
Study (year) (Ref)(years)(n)(%)(%)
Da Qing IGT and Diabetes Study (1997) (102)Chinese:Total n = 577Control: 67.7Diet: 31.0
BMI: 26.06Control: 133Diet: 43.8Exercise: 46.0
Age: 45.0Diet: 130Exercise: 41.1Diet + exercise: 42.0
Cluster randomized by clinicExercise: 141Diet + exercise: 46.0
Diet + exercise: 126
Da Qing Diabetes Prevention Study (2008) (103)ControlControl: 138Control: 93.043.0
BMI: 24.420Intervention: 439Intervention: 80.0
Intervention
BMI: 24.5
Da Qing Diabetes Prevention Study (2014) (103)ControlTotal n = 568 (by interview from medical records)Control: 89.945.0
BMI: 25.723Control: 138Intervention: 72.6
InterventionIntervention: 430CVD mortality41.0
BMI: 26.2Control: 19.6
Intervention: 11.9
All-cause mortality29.0
Control: 38.4
Intervention: 28.0
IDPP-1 (2006) (104)BMI: 25.82.6 (median)Total n = 531Control: 55.0LSM: 28.5
Age: 45.9Control: 136LSM: 39.3Metformin: 26.4
Persistent IGT, individual randomizationLSM: 133Metformin: 40.5LSM + metformin: 28.2
Metformin: 133LSM + metformin: 39.5
LSM + metformin: 129
Indian SMS study (2013) (108)BMI: 25.82Control: 266Control: 27.4
Age: 45.9Intervention: 271Intervention: 18.536.0
Persistent IGT, men
Japanese prevention study (2005) (105)Japanese men:4Control: 102Control: 9.367.4
BMI: 23.5Intervention: 356Intervention: 3.0
Age: 51.5
IGT, individual randomization
Zensharen Study for Prevention of Lifestyle Diseases (2011) (106)Japanese men:3Control: 330Control: 16.644.0
BMI: 27.0Intervention: 311Intervention: 12.2
Age: 49.0
IGT, individual randomization
  • Age given as mean (years) and BMI given as mean (kg/m2). CVD, cardiovascular disease.