Table 1

Baseline characteristics of the 917,440 patients with diabetes in the study sample by hypoglycemia status: the SUPREME-DM studya

TotalSevere hypoglycemic events/year
None1 severe≥2 severe
(N = 917,440)(n = 875,062)(n = 41,063)(n = 1,315)P valueb
Person-years of time at risk4,322,7864,085,965232,7474,075
Female (%)47.947.849.047.5<0.001
Age, mean (SD), years57.9 (13.2)57.7 (13.2)61.0 (13.2)60.5 (15.2)<0.001
Comorbidities (%)
 CKD10.49.529.149.0<0.001
 CVD18.718.034.249.0<0.001
 CHF4.94.512.923.3<0.001
 Depression11.111.111.016.0<0.001
Comorbidity index, mean (SD)c2.70 (1.98)2.70 (1.96)2.96 (2.31)3.98 (2.97)<0.001
Follow-up, mean (SD), years4.71 (2.18)4.67 (2.18)5.67 (1.81)3.10 (1.97)<0.001
  • aStudy includes patients with a minimum of 1 year of follow-up after diabetes identification.

  • bThree-way comparison between 0, 1, and ≥2 severe hypoglycemic events/year.

  • cQuan modification of the Elixhauser comorbidity index (37).