Table 2

Brain volumes by intervention assignment

Brain volumesDSEILIP value
Adjusted for intracranial volume, age, and clinical site
 Gray matter601.39 (2.25)604.59 (2.16)0.31
 White matter497.82 (1.40)498.35 (1.35)0.78
 Total brain1,104.10 (2.02)1,106.25 (1.94)0.44
 Hippocampus7.70 (0.05)7.67 (0.05)0.78
 Total white matter hyperintensity*2.21 (1.11)1.59 (1.11)0.02
 Ventricle*31.72 (1.03)28.93 (1.03)0.04
Additionally adjusted for baseline BMI
 Gray matter601.29 (2.26)604.71 (2.17)0.28
 White matter497.62 (1.40)498.57 (1.35)0.63
 Total brain1,103.73 (2.02)1,106.68 (1.94)0.29
 Hippocampus7.69 (0.05)7.68 (0.05)0.87
 Total white matter hyperintensity*2.20 (1.11)1.59 (1.11)0.03
 Ventricle*31.82 (1.03)28.82 (1.03)0.03
  • Data are mean (SE) (cubic centimeters) unless otherwise indicated. The prespecified primary outcome was total brain volume. Volumes of total white matter hyperintensities and the hippocampus were prespecified as secondary outcomes. The additional MRI outcomes are presented as supporting data.

  • *Log-transformed volumes are presented as back-transformed mean (SE).