Table 1

Clinical profile and mortality of patients with T2DM (N = 1,416) grouped by age of diagnosis and matched for diabetes duration

T2DM15–30T2DM40–50Test statistics
n = 354n = 1,062P value
Age diagnosed (years)25.6 ± 3.745.2 ± 2.9<0.0001
Duration of diabetes at last visit (years)11.6 (4.5–22.6)11.4 (4.5–21.7)Matched
Male (%)50.650.6Matched
Age at last visit (years)40.4 ± 12.659.1 ± 10.7<0.0001
Family history of diabetes (%)80.967.1<0.0001
Number of family members affected with diabetes2.4 ± 2.02.0 ± 1.60.02
Updated HbA1c
 Percentage (%)8.1 ± 1.68.0 ± 1.70.3
 IFCC (mmol/mol)65.5 ± 17.764.3 ± 18.20.3
Diabetes treatment (%)0.0002**
 Diet9.68.2
 Tablets37.349.9
 Insulin53.141.9
BMI (kg/m2)32.2 ± 7.631.2 ± 7.40.04
Blood pressure (mmHg)
 Systolic126 ± 17132 ± 19<0.0001
 Diastolic78 ± 1077 ± 110.2
Blood pressure treatment (%)49.368.1<0.0001
Cholesterol (mmol/L)5.2 ± 1.54.8 ± 1.2<0.001
Triglyceride (mmol/L)1.9 (1.3–3.0)1.6 (1.2–2.5)0.001
Statin treatment (%)38.151.50.0001
Smoking (%)41.345.30.2
Retinopathy (%)37.035.40.5
Vibration perception threshold Z score* 2.3 ± 1.32.0 ± 1.20.003
Albuminuria (%)47.441.10.07
Urine albumin concentration (mg/L)19.1 (6.0–114.1)14.5 (6.5–49.0)0.004
Any macrovascular disease (%)14.423.7<0.0001
Peripheral arterial disease (%)3.86.50.07
Ischemic heart disease (%)12.617.50.02
Stroke (%)4.37.00.1
Death, n (%)39 (11.0)204 (19.2)<0.0001
Age at the time death (years)52.9 ± 4.768.6 ± 12.4<0.0001
Duration of diabetes at the time of death (years)26.9 (18.1–36.0)25.1 (15.3–32.0)<0.0001
Cause of death (%)0.7**
 Vascular50.042.8
 Cancer7.110.1
 Other42.947.1
  • Results are presented as mean ± SD, as median (IQR), or as indicated.

  • IFCC, International Federation of Clinical Chemistry and Laboratory Medicine.

  • *Vibration perception threshold is tested by biothesiometer adjusted for age by expressing data as a Z score.

  • **P for differences in the distribution of the three categories between groups.